In 1959 Dr. Patricia Jacobs and her team in Edinburgh, Scotland at the Western General Hospital, coined Triple-X as the name of the syndrome. Ever since there has been quite some scientific research. But a medicine or “cure” does not exist. Hundred thousands of families each on their own go through life with a third x-chromosome (47,xxx) in one of their daughters, siblings, wifes or partners. Every 1000th woman on earth is born with it, only about 10% are diagnosed, often by chance. But that there is no “cure” does not mean that there is no approach to support and improve life with Triple-X and this network will off many strategies which are all ready in practice world wide.